Two 2 ERBA-related genes, named EAR2 and EAR3 , are predicted to encode proteins very similar in primary structure to
receptors for steroid hormones and thyroid hormone. In addition, the amino acid sequences of the 2 gene products are
very similar to each other, especially in the DNA-binding domain (86% homology) and at the putative ligand-binding
domain (76% homology).
DNA binding, Transcription factor
Expression regulated by
and Maria L. Dufau 2001 reported that EAR2 and EAR3/COUP-TFI Regulate Transcription
of the Rat LH Receptor.
hCG treatment significantly reduced the inhibition of LHR gene in granulosa cells and also decreased EAR2 and EAR3/COUP-TFI protein levels. These results indicate that hormonally regulated expression of EAR2 and EAR3/COUP-TFI contributes to gonadotropin-induced derepression of LHR promoter activity in granulosa cells.