The EPH and EPH-related receptors comprise the largest subfamily of receptor
protein-tyrosine kinases. They have been implicated in mediating developmental events,
particularly in the nervous system. Receptors in the Eph subfamily typically have a
single kinase domain and an extracellular region containing a Cys-rich domain and 2
fibronectin type III repeats.
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.