SMAD8; MOTHERS AGAINST DECAPENTAPLEGIC, DROSOPHILA, HOMOLOG OF, 8; MADH8 OKDB#: 1641
 Symbols: SMAD8; MOTHERS AGAINST DECAPENTAPLEGIC, DROSOPHILA Species: human
 Synonyms:  Locus:


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General Comment 'Mothers against decapentaplegic'-related proteins (MADRs) are intracellular components that play critical roles in signal transduction pathways involving the transforming growth factor-beta.
General function
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Cellular localization Cytoplasmic
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Ovarian function Follicle development
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Expression regulated by
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Ovarian localization Oocyte, Granulosa, Theca
Comment Drummond AE, et al reported the expression and localization of activin receptors, Smads, and beta glycan to the postnatal rat ovary. The expression of activin/BMP receptor, Smad, and beta glycan mRNAs by postnatal rat ovaries were investigated by real-time PCR. Activin/BMP receptors (ActRIA, ActRIB, ActRIIA, and ActRIIB), beta glycan, and Smad 1-8 mRNAs were expressed by the ovary. Activin receptor and Smad 1, 2, 4, 5, and 7 mRNAs declined up to 4-fold between postnatal d 4-8, coinciding with secondary follicle formation. The emergence of antral follicles (postnatal d 12) saw ActRIA, ActRIIB, and Smad 2 mRNA expression return to d 4 levels, whereas ActRIB, ActRIIA, and Smads 1, 4, 5, and 7 remained at lower levels. beta glycan mRNA levels increased 2-fold between d 8 and 12, suggesting expression by the developing theca. Smad 3, 6, and 8 mRNAs were unchanged. Activin receptor and Smad proteins were present in oocytes at all stages of follicular development; granulosa cells of primary-antral follicles, and theca cells. beta glycan protein was present in oocytes, granulosa cells, and theca cells at all stages of folliculogenesis. The colocalization of receptors and Smads supports the notion that activin/TGF beta and BMP signaling pathways are functional in the cellular compartments of the follicle.
Follicle stages Secondary, Antral
Comment
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created: 2002-11-03 07:50:15 by: Aaron J Hsueh, hsuehlab   email: aaron.hsueh@stanford.edu
home page: http://reprobio.stanford.edu/hsueh



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