Melanoma Antigen, Family C, 1 OKDB#: 1742
 Symbols: MAGEC1 Species: human
 Synonyms:  Locus: Xq26 in Homo sapiens
HPMR


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General Comment Genes of the MAGE family direct the expression of tumor antigens that are recognized on a human melanoma by autologous cytolytic T lymphocytes. The MAGE genes were initially isolated from different kinds of tumors, and based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy. However, although a large number of MAGE genes have now been identified and extensively studied in tumors of various origin, their functions in normal cells remain unknown.
General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function
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Expression regulated by
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Ovarian localization Tumor cells
Comment Jungbluth AA, et al 2002 reported that CT7 (MAGE-C1) antigen expression in normal and neoplastic tissues, including ovarian carcinomas.
Follicle stages
Comment
Phenotypes
Mutations
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: 2003-03-19 10:25:57 by: Aaron J Hsueh, hsuehlab   email: aaron.hsueh@stanford.edu
home page: http://reprobio.stanford.edu/hsueh



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