Transporter, Atp-binding Cassette, Major Histocompatibility Complex, 1 OKDB#: 3186
 Symbols: TAP1 Species: human
 Synonyms: APT1, PSF1, ABC17, ABCB2, RING4, TAP1N, D6S114E, FLJ26666, TAP1*0102N,TRANSPORTER, ABC, MHC, 1|ATP-BINDING CASSETTE, SUBFAMILY B, MEMBER 2, ABCB2|ATP-BINDING CASSETTE TRANSPORTER, MAJOR HISTOCOMPATIBILITY COMPLEX, 1|ABC TRANSPORTER, MHC, 1|PEPTIDE TRANSPO  Locus: 6p21.3 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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R-L INTERACTIONS   MGI

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General Comment

NCBI Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.
General function Channel/transport protein
Comment
Cellular localization
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Ovarian function
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Expression regulated by
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Ovarian localization
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Follicle stages Primordial
Comment Arraztoa JA, et al 2005 reported the identification of genes expressed in primate primordial oocytes.
Phenotypes
Mutations
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
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Related Genes
Beta
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created: 2006-06-21 12:44:06 by: Alex C Yee, hsuehlab   email: alex.c.yee@gmail.com
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last update: 2006-06-21 13:29:50 by: Alex C Yee, hsuehlab   email: alex.c.yee@gmail.com



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