sperm associated antigen 5 OKDB#: 3878
 Symbols: SPAG5 Species: human
 Synonyms: MAP126, DEEPEST, hMAP126,  Locus: 17q11.2 in Homo sapiens

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DNA Microarrays
link to BioGPS
General Comment

NCBI Summary: This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. [provided by RefSeq]
General function Chromosome organization
Cellular localization
Ovarian function
Expression regulated by
Ovarian localization Oocyte
Comment Allegro: Analyzing expression and sequence in concert to discover regulatory programs. Halperin Y et al. A major goal of system biology is the characterization of transcription factors and microRNAs (miRNAs) and the transcriptional programs they regulate. We present Allegro, a method for de-novo discovery of cis-regulatory transcriptional programs through joint analysis of genome-wide expression data and promoter or 3' UTR sequences. The algorithm uses a novel log-likelihood-based, non-parametric model to describe the expression pattern shared by a group of co-regulated genes. We show that Allegro is more accurate and sensitive than existing techniques, and can simultaneously analyze multiple expression datasets with more than 100 conditions. We apply Allegro on datasets from several species and report on the transcriptional modules it uncovers. Our analysis reveals a novel motif over-represented in the promoters of genes highly expressed in murine oocytes. The present gene id highly expressed in the oocyte and has a unique promoter motif.
Follicle stages
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created: 2009-01-25 11:19:27 by: Aaron J Hsueh, hsuehlab   email: aaron.hsueh@stanford.edu
home page: http://reprobio.stanford.edu/hsueh
last update: 2009-01-25 11:20:00 by: Aaron J Hsueh, hsuehlab   email: aaron.hsueh@stanford.edu

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