double homeobox B-like OKDB#: 4166
 Symbols: Duxbl Species: human
 Synonyms: RGD1311053,  Locus: 16p16 in Homo sapiens


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R-L INTERACTIONS   MGI

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General Comment
General function DNA binding, Transcription factor
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Cellular localization Nuclear
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Ovarian function
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Expression regulated by
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Ovarian localization Oocyte
Comment Characterization of genomic structures and expression profiles of three tandem repeats of a mouse double homeobox gene: Duxbl. Wu SL et al. We identified and cloned a mouse double homeobox gene (Duxbl), which encodes two homeodomains. Duxbl gene, a tandem triplicate produces two major transcripts, Duxbl and Duxbl-s. The amino acid sequences of Duxbl homeodomains are most similar to those of human DUX4 protein, associated with facioscapulohumeral muscular dystrophy. In adult tissues, Duxbl is predominantly expressed in female reproductive organs and eyes, and slightly expressed in brain and testes. During gonad development, Duxbl is expressed from embryonic to adult stages and specifically expressed in oocytes and spermatogonia. During embryonic development, Duxbl is transcribed in limbs and tail. However, Duxbl proteins were only detected in trunk and limb muscles and in elongated myocytes and myotubes. In C2C12 muscle cell line, Duxbl expression pattern is similar to differentiated marker gene, Myogenin, increased in expression from 2 days onward in differentiating medium. We suggest that Duxbl proteins play regulatory roles during myogenesis and reproductive developments. Developmental Dynamics, 2010. (c) 2010 Wiley-Liss, Inc.
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created: 2010-01-13 11:31:21 by: Aaron J Hsueh, hsuehlab   email: aaron.hsueh@stanford.edu
home page: http://reprobio.stanford.edu/hsueh
last update: 2010-01-13 11:31:23 by: Aaron J Hsueh, hsuehlab   email: aaron.hsueh@stanford.edu



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