DNA Array
Beta
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General Comment |
Adenylyl cyclase (EC 4.6.1.1 ) catalyzes the transformation of ATP into cyclic AMP. The enzymatic activity is under the
control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the
catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase
activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase.
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General function |
Intracellular signaling cascade, Enzyme, Transferase
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Comment |
Adenylyl cyclase is the prototypical second messenger generator. There are at least nine eight cloned membrane-bound adenylyl cyclases together with the testis soluble adenyl cyclase. The membrane bound enzymes are regulated by diverse G proteins and are regulated by one or other arm of the
phospholipase C pathway. In addition to ligand-mediated signaling via G proteins, functional and ultrastructural investigations have
shown that adenylyl cyclases are also intimately associated with sites of calcium ion
entry into the cell.
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Cellular localization |
Plasma membrane
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Comment |
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Ovarian function |
Follicle development, Primary follicle growth, Preantral follicle growth, Antral follicle growth, Follicle atresia, Ovulation, Steroid metabolism, Luteinization
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Comment |
Adenyl cyclase is important in mediating the actions of gonadotropins, VIP and other hormones in the ovary.
Leung PC, et al. reviewed intracellular signaling in the gonads.
Rojas FJ, et al. reviewed the role of the adenylyl cyclase system in the regulation of corpus luteum function in the human and in nonhuman
primates.
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Expression regulated by |
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Comment |
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Ovarian localization |
Cumulus, Granulosa, Theca, Luteal cells, Small luteal cells, Large luteal cells
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Comment |
This gene was found in a rat ovarian cDNA library (Unigene).
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Follicle stages |
Primary, Secondary, Antral, Preovulatory, Corpus luteum
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Comment |
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Mutations |
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Links |
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Related Genes
Beta
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Show data ...
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