Cadherin 3 OKDB#: 833
 Symbols: CDH3 Species: human
 Synonyms: CADHERIN, PLACENTAL| P-CADHERIN, PCAD| CALCIUM-DEPENDENT ADHESION PROTEIN, PLACENTAL| CDHP|  Locus: 16q22.1 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment P-Cadherin is a specific calcium ion-dependent cell adhesion molecule. The Ca2+-dependent cell adhesion molecules, termed cadherins, were originally divided into two subclasses, E- and N-types, with different adhesive specificity. Nose et al identified a novel class of cadherin, termed P-cadherin.

NCBI Summary: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas.
General function Cell adhesion molecule
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Cellular localization Plasma membrane
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Ovarian function fertilization
Comment Expression of cadherin molecules was demonstrated by Rufas et al in human oocyte using an anti-pan-cadherin antibody and specific antibodies against the three classical cadherins: E- (epithelial), P- (placental) and N- (neural) cadherins. Samples of 48 h old unfertilized oocytes were lysed and separated by electrophoresis. Localization of cadherins was determined on intact, fixed, permeabilized oocytes by immunocytochemisty assessed by confocal microscopy. Immunoblotting with the pan-cadherin antibody revealed a single band of ~120 kDa in oocyte extracts. Oocytes presented all three classical cadherins with the appropriate molecular weights of 120130 kDa. Following immunocytochemistry of human oocytes all cadherin molecules were allocated predominantly to the plasma membrane with only traces in the cytoplasm. It was concluded that cadherin molecules are present on plasma membranes of both human spermatozoa and oocytes and may play a role in the intricate recognition process preceding gamete fusion.
Expression regulated by
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Ovarian localization Oocyte
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Follicle stages Preovulatory
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created: 2000-02-13 00:00:00 by: Aaron J Hsueh, hsuehlab   email: aaron.hsueh@stanford.edu
home page: http://reprobio.stanford.edu/hsueh
last update: 2001-08-14 08:55:28 by: Emilee  Wilhelm,    email: ewilhelm@stanford.edu



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