macrophage stimulating 1 (hepatocyte growth factor-like) OKDB#: 862
 Symbols: MST1 Species:
 Synonyms: MSP, HGFL, NF15S2, D3F15S2, DNF15S2,HEPATOCYTE GROWTH FACTOR-LIKE PROTEIN, HGFL|MACROPHAGE STIMULATING PROTEIN, MSP  Locus: 3p21 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment

NCBI Summary: The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010]
General function
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Cellular localization
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Ovarian function
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Expression regulated by
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Ovarian localization tumor cells
Comment Shigemasa K, et al. reported that The mRNA expression level of p16 was significantly elevated in 28 ovarian tumors (22 carcinomas, five low malignant potential tumors, and one benign tumor) compared with that of normal ovaries. Western blotting analysis and immunohistochemical staining confirmed elevated p16 protein levels in ovarian tumor samples. Among 32 ovarian tumors, cDNA sequencing of the p16 gene showed no p16 mutation resulting in a coding error, although one silent mutation and three polymorphisms were found. Although p16 is seldom mutated in ovarian tumors, the overexpression of p16 in most ovarian tumor cases indicates a dysfunction in the regulatory complex for G1 arrest. Therefore, overexpression of p16 may be an important early event in the neoplastic transformation of the ovarian epithelium.
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Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: 2000-02-18 00:00:00 by:   ,    email:
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last update: 2011-10-25 16:47:49 by: Aaron J Hsueh, hsuehlab   email: aaron.hsueh@stanford.edu



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