Ligand, Growth factor, Cell death/survival, Anti-apoptotic Glial Cell Line-derived Neurotrophic Factor OKDB#: 110
Symbols: GDNF Species: human
Synonyms: Glial cell line-derived neurotrophic factor; GDNF Ovarian localization: Oocyte, Granulosa, Ovarian tumor
Is involved in interactions with:

1)
GFRA2, GDNF family receptor alpha 2 OKdb  (Ovarian localization: )
  and
RET, Proto-oncogene tyrosine-protein kinase receptor ret precursor HPMR (NOT-IN-OKDB)
Comments: Baloh et al. (1997) reported that TrnR2 mediates GDNF signaling through Ret. This was also supported by Suvanto et al. and Klein et al..

2)
GFRA1, GDNF family receptor alpha 1 isoform a preproprotein OKdb  (Ovarian localization: Oocyte Granulosa)
  and
RET, Proto-oncogene tyrosine-protein kinase receptor ret precursor HPMR (NOT-IN-OKDB)
Comments: The RET receptor tyrosine kinase is activated by binding to a ligand complex formed by a member of the glial cell line-derived neurotrophic factor (GDNF) family of neurotrophic factors bound to its cognate GDNF-family receptor-alpha (GFR alpha) glycosylphosphatidylinositol-linked co-receptor (Kjaer & Ibanez 2003). (Saarma et al. 2000)undefined

3)
RET, Proto-oncogene tyrosine-protein kinase receptor ret precursor HPMR (NOT-IN-OKDB)
Comments: Genomic structure and chromosomal localization of the human GDNFR-alpha gene. Oncogene. 1998

Data Supplied By HPMR